Upstream and Downstream Regulation of Asexual Development in Aspergillus fumigatus
نویسندگان
چکیده
منابع مشابه
Upstream and downstream regulation of asexual development in Aspergillus fumigatus.
The opportunistic human pathogen Aspergillus fumigatus produces a large quantity of asexual spores (conidia), which are the primary agent causing invasive aspergillosis in immunocompromised patients. We investigated the mechanisms controlling asexual sporulation (conidiation) in A. fumigatus via examining functions of four key regulators, GpaA (Galpha), AfFlbA (RGS), AfFluG, and AfBrlA, previou...
متن کاملAspergillus fumigatus RasA regulates asexual development and cell wall integrity.
The Ras family of proteins is a large group of monomeric GTPases. Members of the fungal Ras family act as molecular switches that transduce signals from the outside of the cell to signaling cascades inside the cell. A. fumigatus RasA is 94% identical to the essential RasA gene of Aspergillus nidulans and is the Ras family member sharing the highest identity to Ras homologs studied in many other...
متن کاملRegulation of Development in Aspergillus nidulans and Aspergillus fumigatus
Members of the genus Aspergillus are the most common fungi and all reproduce asexually by forming long chains of conidiospores (or conidia). The impact of various Aspergillus species on humans ranges from beneficial to harmful. For example, several species including Aspergillus oryzae and Aspergillus niger are used in industry for enzyme production and food processing. In contrast, Aspergillus ...
متن کاملReproduction in Aspergillus fumigatus: sexuality in a supposedly asexual species?
Aspergillus fumigatus has long been considered to reproduce only by asexual means. However, accumulating evidence suggest that a sexual stage for A. fumigatus may yet be identified. We describe results from published and ongoing studies involving population genetic analyses, genome analysis, studies of mating-type gene presence and distribution, expression of sex-related genes, and taxonomic wo...
متن کاملMating type protein Mat1-2 from asexual Aspergillus fumigatus drives sexual reproduction in fertile Aspergillus nidulans.
The lack of an experimentally amenable sexual genetic system in Aspergillus fumigatus is a major limitation in the study of the organism's pathogenesis. A recent comparative genome analysis revealed evidence for potential sexuality in A. fumigatus. Homologs of mating type genes as well as other genes of the "sexual machinery" have been identified in anamorphic A. fumigatus. The mat1-2 gene enco...
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ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2006
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.00192-06